Glibenclamide prevents increased extracellular matrix formation induced by high glucose concentration in mesangial cells.

@article{Giannico2007GlibenclamidePI,
  title={Glibenclamide prevents increased extracellular matrix formation induced by high glucose concentration in mesangial cells.},
  author={G. Giannico and P. Cort{\'e}s and M. H. Baccora and C. Hassett and D. Taube and J. Yee},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={292 1},
  pages={
          F57-65
        }
}
Other than stimulation of cell contractility, little is known about the potential metabolic effects induced by sulfonylureas, independently of insulin action. Previous studies from our laboratory demonstrated complete abrogation of glomerulosclerosis in an experimental model of type 1 diabetes chronically (9 mo) treated with low-dose sulfonylureas (Biederman JI, Vera E, Pankhaniya R, Hassett C, Giannico G, Yee J, Cortes P. Kidney Int 67: 554-565, 2005). Therefore, the effects of glibenclamide… Expand
Glibenclamide Induces Collagen IV Catabolism in High Glucose-Stimulated Mesangial Cells
TLDR
Low dosage/concentration Glib prevents HG-induced collagen accumulation in MC by enhancing collagen catabolism in a cAMP-PKA-mediated PAI-1 inhibition. Expand
Effects of long-term elevated glucose on collagen formation by mesangial cells.
TLDR
The studies suggest that prolonged exposure to HG results in PKC-delta-driven collagen accumulation by MCs mediated by PAI-1 but independent of TGF-beta. Expand
N-Acetylcysteine-Mediated Antioxidation Prevents Hyperglycemia-Induced Apoptosis and Collagen Synthesis in Rat Mesangial Cells
TLDR
It is concluded that NAC prevents HG-induced mesangial apoptosis and fibrogenesis pathways by the reduction of oxidative stress. Expand
Purple corn anthocyanins dampened high-glucose-induced mesangial fibrosis and inflammation: possible renoprotective role in diabetic nephropathy.
TLDR
There was a crosstalk between TGF-β-SMAD and NF-κB pathways in the diabetes-associated mesangial fibrosis and inflammation, which appeared to be severed by PCA. Expand
Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing KATP channel
TLDR
In contrast to glibenclamide and glimepiride, therapeutic concentrations of gliclazide showed an inhibitory effect on apoptosis of PTECs, which may have a benefit in the preservation of functionalPTECs mass. Expand
Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction.
TLDR
DKK1 mediates HG-induced destabilization of beta-catenin and matrix accumulation in mesangial cells and prevents diabetes-induced renal dysfunction and microstructure deterioration, suggesting that inhibition of DKK1 offers therapeutic potential for diabetic nephropathy. Expand
All-trans retinoic acid inhibits the increases in fibronectin and PAI-1 induced by TGF-β1 and Ang II in rat mesangial cells
TLDR
Results indicate that atRA inhibits the increases in fibronectin that are induced by TGF-β1 and Ang II in cultured glomerular mesangial cells, and suggest that this effect of atRA is associated with a change in PAI-1 levels. Expand
Histological assessment of the possible protective role of glimepiride against progression of experimentally induced diabetic nephropathy in rats
Introduction: little is known about the potential effects induced by sulphonylureas independently of their anti-hyperglycemic action. The present study examined the effect of glimepiride treatment onExpand
Comparison of the effects of glibenclamide on metabolic parameters, GLUT1 expression, and liver injury in rats with severe and mild streptozotocin-induced diabetes mellitus.
TLDR
The GLUT1 expression was found to be affected by the glucose and insulin levels and can be modulated by glibenclamide in severely and mildly diabetic rats. Expand
Anti-diabetic treatment regulates pro-fibrotic TGF-β serum levels in type 2 diabetics
TLDR
The results suggest that glargine/metformin and DPP4i/ Metformin treatment may more effectively reduce active TGF-β serum levels than the sulfonylurea/met formin treatment. Expand
...
1
2
...

References

SHOWING 1-10 OF 58 REFERENCES
Effects of oral antihyperglycemic agents on extracellular matrix synthesis by mesangial cells.
TLDR
Tolazamide markedly enhances ECM synthesis and accumulation in MCs probably by stimulating GLUT1 expression, glucose transport and TGF-beta 1 secretion, irrespective of the ambient glucose concentration, and was dose-dependent and minimally inducible by metformin. Expand
Direct effects of glimepiride on protein expression of cardiac glucose transporters.
  • J. Eckel
  • Biology, Medicine
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 1996
TLDR
It is concluded that glimepiride increases cardiac glucose uptake by an insulin-independent pathway most probably involving an increased protein expression of GLUT1 and GLUT4. Expand
PKC and high glucose stimulate collagen alpha 1 (IV) transcriptional activity in a reporter mesangial cell line.
TLDR
High glucose levels promote transcriptional activity of COL4A1 gene in this reporter mesangial cell line, perhaps through PKC activation, as evidence that stimulation of matrix synthesis is important in early diabetic glomerulopathy. Expand
Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype.
TLDR
Gl glucose transport activity is an important modulator of ECM formation by MCs; the presence of high extracellular glucose concentrations is not necessarily required for the stimulation of matrix synthesis. Expand
Characterization of the rat mesangial cell type 2 sulfonylurea receptor.
TLDR
Functional activation of this receptor by sulfonylurea induces Ca2+ transients that result in MC contraction, demonstrating that SUR2 resides on MCs. Expand
Glycated albumin stimulates TGF-beta 1 production and protein kinase C activity in glomerular endothelial cells.
TLDR
By reducing the proliferative capacity, which is likely mediated by PKC and partly by TGF-beta, glycated albumin impedes the ability of the glomerular capillary endothelium to act as a first line of defense against deleterious circulating factors in the diabetic state. Expand
Rat mesangial α-endosulfine
TLDR
Mesangial cell expression of ENSA, the gene encoding α-endosulfine, and its regulation by glucose are investigated to find potential roles as a regulator of metabolism and contractility via mesangial cells K ATP. Expand
The Sulfonylurea Drug, Glimepiride, Stimulates Glucose Transport, Glucose Transporter Translocation, and Dephosphorylation in Insulin-Resistant Rat Adipocytes In Vitro
TLDR
It is concluded that glimepiride activates glucose transport by stimulation of GLUT1 and GLUT4 translocation in rat adipocytes via interference at a site downstream of the putative molecular defect in the signaling cascade between the insulin receptor and the glucose transport system induced by high concentrations of glucose and insulin. Expand
Advanced glycosylation end products stimulate collagen mRNA synthesis in mesangial cells mediated by protein kinase C and transforming growth factor-beta.
TLDR
It is suggested that AGE-BSA stimulates collagen mRNA expression by activating PKC and the transcriptional upregulation of TGF-beta1 in HMCs, which may function as key signaling intermediaries in the AGE up-regulated collagen gene expression pathway in H MCs. Expand
Sulfonylurea-Stimulated Glucose Transport Association With Diacylglycerollike Activation of Protein Kinase C in BC3H1 Myocytes
TLDR
It is suggested that tolbutamide and glyburide increase glucose uptake in BC3H1 myocytes by a postreceptor mechanism, which may involve direct activation of protein kinase C. Expand
...
1
2
3
4
5
...