Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats.

@article{FigueroaValverde2012Glibenclamidepregnenolone,
  title={Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats.},
  author={Lauro Figueroa-Valverde and F. D{\'i}az-cedillo and Maria de Lourdes Lopez-Ramos and Elodia Garc{\'i}a-Cervera and Eduardo Pool-G{\'o}mez and Carlos Cardena-Arredondo and Graciela Ancona-Leon},
  journal={Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia},
  year={2012},
  volume={156 2},
  pages={122-7}
}
AIM The present study was designed to investigate the activity of two glibenclamide derivatives on glucose concentration. An additional aim was to identify the biodistribution of glibenclamide derivatives in different organs in a diabetic animal model. METHODS The effects of two glibenclamide derivatives on glucose concentration were evaluated in a diabetic animal model. In addition, glibenclamide derivatives were bound to Tc-99m using radioimmunoassay methods. To evaluate the… CONTINUE READING
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