Glibenclamide is superior to decompressive craniectomy in a rat model of malignant stroke.

@article{Simard2010GlibenclamideIS,
  title={Glibenclamide is superior to decompressive craniectomy in a rat model of malignant stroke.},
  author={J. Marc Simard and Natalia Tsymbalyuk and Orest Tsymbalyuk and Svetlana G. Ivanova and Vladimir V. Yurovsky and Volodymyr Gerzanich},
  journal={Stroke},
  year={2010},
  volume={41 3},
  pages={531-7}
}
BACKGROUND AND PURPOSE Treating patients with malignant cerebral infarctions remains a major unsolved problem in medicine. Decompressive craniectomy (DC) improves the bleak outlook but is suboptimal. Using a rat model of severe ischemia/reperfusion with very high mortality due to malignant cerebral edema, we tested the hypothesis that blocking of sulfonylurea receptor 1-regulated NC(Ca-ATP) channels with glibenclamide would compare favorably to DC when reperfusion and treatment were begun 6… CONTINUE READING
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