Glibenclamide depresses the slowly inactivating outward current (ID) in hippocampal neurons.

@article{Crpel1992GlibenclamideDT,
  title={Glibenclamide depresses the slowly inactivating outward current (ID) in hippocampal neurons.},
  author={Val{\'e}rie Cr{\'e}pel and Kre{\vs}imir Krnjevi{\'c} and Yehezkel Ben-Ari},
  journal={Canadian journal of physiology and pharmacology},
  year={1992},
  volume={70 2},
  pages={306-7}
}
Sulphonylurea drugs, such as glibenclamide and tolbutamide, are widely used as selective blockers of adenosine triphosphate-sensitive K channels. In experiments on hippocampal slices (from Wistar rats) glibenclamide (and possibly gliquidone and tolbutamide) significantly reduced the highly voltage-dependent, 4-aminopyridine-sensitive D-type outward current of CA3 neurons. Judging by these observations, the sulphonylureas may not be as selective as generally believed.