Glibenclamide and meglitinide block the transport of low molecular weight solutes into malaria-infected erythrocytes.

@article{Kirk1993GlibenclamideAM,
  title={Glibenclamide and meglitinide block the transport of low molecular weight solutes into malaria-infected erythrocytes.},
  author={Kiaran Kirk and Heather A. Horner and Dominique J. Spillett and Barry C Elford},
  journal={FEBS letters},
  year={1993},
  volume={323 1-2},
  pages={123-8}
}
Following infection by the malaria parasite, human erythrocytes show increased uptake of a wide variety of low molecular weight solutes via pathways with functional characteristics different from those of the transporters of normal erythrocytes. In this study glibenclamide and meglitinide were shown to inhibit the induced transport of a sugar alcohol (sorbitol), an amino acid (threonine), an inorganic anion (Cl-) and an organic cation (choline) into human erythrocytes infected in vitro with… CONTINUE READING