Glial swelling and astrogliosis produce diffusion barriers in the rat spinal cord.

@article{Sykov1999GlialSA,
  title={Glial swelling and astrogliosis produce diffusion barriers in the rat spinal cord.},
  author={Eva Sykov{\'a} and Lydia Vargova and S Prokopov{\'a} and Zuzana Simonov{\'a}},
  journal={Glia},
  year={1999},
  volume={25 1},
  pages={56-70}
}
Cell swelling and astrogliosis (manifested as an increase in GFAP) were evoked in isolated rat spinal cords of 4-21-day-old rats by incubation in either 50 mM K+ or hypotonic solution (235 mosmol kg(-1)). Application of K+ and hypotonic solution resulted at first in a decrease of extracellular space (ECS) volume fraction alpha (ECS volume/total tissue volume) and an increase in tortuosity lambda (lambda2 = free/apparent diffusion coefficient) in spinal gray (GM) and white matter (WM). These… CONTINUE READING