Glial responses to synaptic damage and plasticity.

  title={Glial responses to synaptic damage and plasticity.},
  author={H{\aa}kan Aldskogius and Liping Liu and Mikael Svensson},
  journal={Journal of neuroscience research},
  volume={58 1},
We review three principally different forms of injury-induced synaptic alterations. (1) Displacement of presynaptic terminals from perikarya and dendrites of axotomized neurons, (2) central changes in primary afferent terminals of peripherally axotomized sensory ganglion cells, and (3) anterograde Wallerian-type degeneration following interruption of central axonal pathways. All these instances rapidly activate astrocytes and microglia in the vicinity of the affected synaptic terminals. The… CONTINUE READING


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