Glial reactivity in ciliary neurotrophic factor-deficient mice after optic nerve lesion.

@article{Martin2003GlialRI,
  title={Glial reactivity in ciliary neurotrophic factor-deficient mice after optic nerve lesion.},
  author={Aliki Martin and Hans-Dieter Hofmann and Matthias Kirsch},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 13},
  pages={5416-24}
}
There is evidence that ciliary neurotrophic factor (CNTF), in addition to its neurotrophic activity, positively regulates astrogliosis after CNS injury. CNTF and its receptor, CNTFRalpha, are strongly upregulated in activated astrocytes. Application of CNTF upregulates GFAP expression in cultured astrocytes and induces various aspects of gliosis in the intact brain. Here we examined whether inactivation of the CNTF gene results in the expected changes in glial reactivity by analyzing gliosis in… CONTINUE READING