Glial growth factor restricts mammalian neural crest stem cells to a glial fate

  title={Glial growth factor restricts mammalian neural crest stem cells to a glial fate},
  author={N. Shah and M. Marchionni and I. Isaacs and P. Stroobant and D. Anderson},
  • N. Shah, M. Marchionni, +2 authors D. Anderson
  • Published 1994
  • Biology, Medicine
  • Cell
  • Growth factors and cytokines are thought to influence the development of uncommitted progenitor cell populations, but the issue of how these factors act on individual cells remains controversial. Such factors may act simply as selective mitogens or survival factors for cells that undergo lineage restrictions stochastically. Alternatively, they may instruct or bias multipotent cells to choose one lineage at the expense of others. Here we show that glial growth factor (GGF), previously defined as… CONTINUE READING
    498 Citations

    Figures, Tables, and Topics from this paper

    Growth factors regulating neural crest cell fate decisions.
    • L. Sommer
    • Biology, Medicine
    • Advances in experimental medicine and biology
    • 2006
    • 29
    Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members
    • 828
    • PDF
    Integration of multiple instructive cues by neural crest stem cells reveals cell-intrinsic biases in relative growth factor responsiveness.
    • N. Shah, D. Anderson
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1997
    • 144
    • PDF
    Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells
    • 719
    Stem cells and transcription factors in the development of the mammalian neural crest
    • D. J. Anderson
    • Biology, Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 1994
    • 45
    The role of notch in promoting glial and neural stem cell fates.
    • 568
    • PDF
    Cytokines regulate the cellular phenotype of developing neural lineage species
    • 68


    Isolation of a stem cell for neurons and glia from the mammalian neural crest
    • 805
    • PDF
    Origins of neural crest cell diversity.
    • 93
    Statistical evidence for a random commitment of pluripotent cephalic neural crest cells.
    • 22
    • PDF
    Control of cell fate in a vertebrate neurogenic lineage
    • 118
    Molecular control of cell fate in the neural crest: the sympathoadrenal lineage.
    • D. Anderson
    • Biology, Medicine
    • Annual review of neuroscience
    • 1993
    • 226
    • PDF
    Small intensely fluorescent cells in culture: role of glucocorticoids and growth factors in their development and interconversions with other neural crest derivatives
    • 190
    • PDF
    Sequential segregation and fate of developmentally restricted intermediate cell populations in the neural crest lineage.
    • J. Weston
    • Biology, Medicine
    • Current topics in developmental biology
    • 1991
    • 161
    Role of the neurotrophic factors BDNF and NGF in the commitment of pluripotent neural crest cells
    • 180
    • Highly Influential