Glial glutamate receptors: likely actors in brain signaling

@article{Teichberg1991GlialGR,
  title={Glial glutamate receptors: likely actors in brain signaling},
  author={Vivian Itzhak Teichberg},
  journal={The FASEB Journal},
  year={1991},
  volume={5},
  pages={3086 - 3091}
}
  • V. Teichberg
  • Published 1 December 1991
  • Biology
  • The FASEB Journal
It has become clear that the neurotransmitter glutamate does not confine its excitatory effects to central nervous system neurons but interacts also with glial cells. Neurons and glia share the same types of ionotropic and metabotropic glutamate receptors except for the N‐methyl‐d‐aspartate receptor, which is not found on glia. Applied on cultured glial cells, glutamate regulates the opening of receptor channels, activates second messengers, and causes the release of neuroactive compounds… 
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References

SHOWING 1-10 OF 43 REFERENCES
Multiple conductance channels in type-2 cerebellar astrocytes activated by excitatory amino acids
TLDR
The experiments show that glial cells possess quisqualate- and kainate-receptor channels but lack receptors for NMDA, and these glutamate channels exhibit multiple conductance levels that are similar in amplitude to the neuronal glutamate channels.
Facilitation of voltage-gated ion channels in frog neuroglia by nerve impulses
TLDR
It is reported that nerve impulses in the axons of the frog optic nerve transiently alter the properties of the voltage-dependent membrane channels of the surface glial cells (astrocytes), a demonstration of a new form of neuron-glia interaction.
Pharmacological characterization of the glutamate receptor in cultured astrocytes
TLDR
It is suggested that astrocytes express one type of glutamate receptor which is activated by both kainate and quisqualate, lending further support to the notion that cultured astroCytes express excitatory amino acid receptors which have some pharmacological similarities to their neuronal counterparts.
Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells
TLDR
It is reported that glutamate evokes a large inward current in retinal glial cells which have their membrane potential and intracellular ion concentrations controlled by the whole-cell patch-clamp technique, and a mechanism for non-vesicular voltage-dependent release of glutamate from neurons is suggested.
Molecular structure of the chick cerebellar kainate-binding subunit of a putative glutamate receptor
TLDR
An oligomeric protein is isolated that displays a pharmacological profile similar to that of a kainate receptor, and the predicted structure of the mature protein has four putative transmembrane domains with a topology analogous to that found in the superfamily of ligand-gated ion channels, raising the possibility, that kainates binding protein may form part of an ion channel and may be a subunit of akainate subtype of glutamate receptor.
Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling.
TLDR
It is reported that cultured hippocampal astrocytes can respond to glutamate with a prompt and oscillatory elevation of cytoplasmic free calcium, visible through use of the fluorescent calcium indicator fluo-3.
Glutamate neurotoxicity in cortical cell culture
TLDR
Some neurons regularly survived brief glutamate exposure; these possibly glutamate-resistant neurons had electrophysiologic properties, including chemosensitivity to glutamate, that were grossly similar to those of the original population.
The excitatory neurotransmitter glutamate causes filopodia formation in cultured hippocampal astrocytes
TLDR
The excitatory neurotransmitter glutamate induces an increase in the number of filopodia on the surface of astrocytes cultured from the neonatal rat hippocampus, associated with a receptor‐mediated event that is activated to a lesser degree by the quisqualate and kainate, but not NMDA receptors.
Kainic acid evokes a potassium efflux from astrocytes
...
1
2
3
4
5
...