Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

@article{Kamphuis2014GlialFA,
  title={Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease},
  author={Willem Kamphuis and Jinte Middeldorp and Lieneke Kooijman and Jacqueline A. Sluijs and E. J. Kooi and Martina Moeton and Michel Freriks and Mark Ronald Mizee and Elly M. Hol},
  journal={Neurobiology of Aging},
  year={2014},
  volume={35},
  pages={492-510}
}
In Alzheimer's disease (AD), amyloid plaques are surrounded by reactive astrocytes with an increased expression of intermediate filaments including glial fibrillary acidic protein (GFAP). Different GFAP isoforms have been identified that are differentially expressed by specific subpopulations of astrocytes and that impose different properties to the intermediate filament network. We studied transcript levels and protein expression patterns of all known GFAP isoforms in human hippocampal AD… CONTINUE READING
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