Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease.

Abstract

Pick's disease is a subset of fronto-temporal dementia characterised by severe atrophy of the temporal and frontal lobes due to marked neuronal loss accompanied by astrocytic gliosis enriched in glial acidic protein. The remaining neurones have intracytoplasmic inclusions composed of hyperphosphorylated tau, called Pick bodies, in addition to… (More)

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@article{Muntan2006GlialFA, title={Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease.}, author={Gerard Muntan{\'e} and Esther Dalf{\'o} and Alvaro Martinez and Mar{\'i}a Jes{\'u}s Rey and Jes{\'u}s {\'A}vila and M F Mart{\'i}n P{\'e}rez and Manuel Portero and Reinald Pamplona and Vict{\'o}ria Ayala and Isidro Ferrer}, journal={Journal of neurochemistry}, year={2006}, volume={99 1}, pages={177-85} }