Glial fibrillary acidic protein gene promoter is differently modulated by transforming growth factor-beta 1 in astrocytes from distinct brain regions.

@article{Sousa2004GlialFA,
  title={Glial fibrillary acidic protein gene promoter is differently modulated by transforming growth factor-beta 1 in astrocytes from distinct brain regions.},
  author={Vivian de Oliveira Sousa and Luciana Ferreira Rom{\~a}o and Vivaldo Moura Neto and Fl{\'a}via Carvalho Alc{\^a}ntara Gomes},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 7},
  pages={1721-30}
}
The expression of glial fibrillary acidic protein (GFAP), the major intermediate filament protein of mature astrocytes, is regulated under developmental and pathological conditions. Recently, we have investigated GFAP gene modulation by using a transgenic mouse bearing part of the GFAP gene promoter linked to the beta-galactosidase reporter gene. We demonstrated that cerebral cortex neurons activate the GFAP gene promoter, inducing transforming growth factor-beta 1 (TGF-beta 1) secretion by… CONTINUE READING

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