Glial expression of the beta-amyloid precursor protein (APP) in global ischemia.

  title={Glial expression of the beta-amyloid precursor protein (APP) in global ischemia.},
  author={Richard B. Banati and Jochen Gehrmann and Christoph Wiessner and K. A. Hossmann and Georg W. Kreutzberg},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={15 4},
The beta-amyloid precursor protein (APP) bears characteristics of an acute-phase protein and therefore is likely to be involved in the glial response to brain injury. In the brain, APP is rapidly synthesized by activated glial cells in response to comparatively mild neuronal lesions, e.g., a remote peripheral nerve injury. Perfusion deficits in the brain result largely in neuronal necrosis and are a common condition in elderly patients. This neuronal necrosis is accompanied by a pronounced… CONTINUE READING


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