Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice.

@article{Kamitani2003GlialEO,
  title={Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice.},
  author={Wataru Kamitani and Etsuro Ono and Saori Yoshino and Tsutomu Kobayashi and Satoshi Taharaguchi and B Lee and Makiko Yamashita and Takeshi Kobayashi and Minoru Okamoto and Hiroyuki Taniyama and Keizo Tomonaga and Kazuyoshi Ikuta},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 15},
  pages={
          8969-74
        }
}
One hypothesis for the etiology of behavioral disorders is that infection by a virus induces neuronal cell dysfunctions resulting in a wide range of behavioral abnormalities. However, a direct linkage between viral infections and neurobehavioral disturbances associated with human psychiatric disorders has not been identified. Here, we show that transgenic mice expressing the phosphoprotein (P) of Borna disease virus (BDV) in glial cells develop behavioral abnormalities, such as enhanced… CONTINUE READING
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