Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation

@article{Hu1999GlialderivedPA,
  title={Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation},
  author={Jingru Hu and Linda J. Van Eldik},
  journal={Brain Research},
  year={1999},
  volume={842},
  pages={46-54}
}
A prominent feature of Alzheimer's disease (AD) pathology is an abundance of activated glia (astrocytes and microglia) in close proximity to the amyloid plaques. These activated glia overexpress a number of proteins that may participate in the progression of the disease, possibly by propagation of inflammatory and oxidative stress responses. The beta-amyloid peptide 1-42 (Abeta), a major constituent of neuritic plaques, can itself induce glial activation. However, little is known about whether… CONTINUE READING
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