Glial-derived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's disease.

@article{Br1997GlialderivedNF,
  title={Glial-derived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's disease.},
  author={Karl J{\"u}rgen B{\"a}r and Paul Facer and Norman S. Williams and Paul K H Tam and P. R. Vijai Anand},
  journal={Gastroenterology},
  year={1997},
  volume={112 4},
  pages={1381-5}
}
BACKGROUND & AIMS Glial cell line-derived neurotrophic factor (GDNF) signals through the product of the ret proto-oncogene, which is known to be mutated in Hirschsprung's disease and other conditions with gut dysmotility. The aim of this study was to determine the presence of GDNF and its receptor component (RET) in human adult and developing intestine and to evaluate their distribution pattern in Hirschsprung's disease. METHODS GDNF and RET were detected immunohistochemically, and GDNF was… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

GDNF is abundant in the adult rat gut.

Journal of the autonomic nervous system • 1998
View 12 Excerpts
Highly Influenced

Gastric electrical stimulation improves enteric neuronal survival

International journal of molecular medicine • 2017
View 1 Excerpt

Glial cell line-derived neurotrophic factor is a key neurotrophin in the postnatal enteric nervous system.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society • 2011

Similar Papers

Loading similar papers…