Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)
@article{Papp1989GlialCI, title={Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)}, author={M{\'a}ty{\'a}s I. Papp and Jacob Kahn and Peter L. Lantos}, journal={Journal of the Neurological Sciences}, year={1989}, volume={94}, pages={79-100} }
844 Citations
Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy
- BiologyActa Neuropathologica
- 2004
The studies demonstrate widespread distribution of NCIs in the central nervous system of MSA and suggest the same pathological process that forms the granule-associated filaments in axons may also be responsible for the formation of ubiquitin-positive thickened neurites.
The distribution and dynamic density of oligodendroglial cytoplasmic inclusions (GCIs) in multiple system atrophy: a correlation between the density of GCIs and the degree of involvement of striatonigral and olivopontocerebellar systems
- BiologyActa Neuropathologica
- 1997
GCIs may represent the early changes in MSA and may be a useful neuropathological hallmark for diagnosis of MSA, even in cases with minimal OPCA and SND.
Argyrophilic ubiquitinated cytoplasmic inclusions of Leu-7-positive glial cells in olivopontocerebellar atrophy (multiple system atrophy)
- BiologyActa Neuropathologica
- 2004
The observation that Leu-7-positive glial cells, mainly oligodendroglials cells, had argyrophilic ubiquitinated inclusions may be of significance for the evaluation of the pathology of OPCA(MSA).
Accumulation of tubular structures in oligodendroglial and neuronal cells as the basic alteration in multiple system atrophy
- BiologyJournal of the Neurological Sciences
- 1992
Cytoskeletal protein abnormalities in patients with olivopontocerebellar atrophy — an immunocytochemical and Gallyas silver impregnation study
- BiologyNeuropathology and applied neurobiology
- 1992
Findings indicate that the argyrophilia in the OPCA subjects closely correlates with PHF and tau immunoreactivities.
Multiple System Atrophy
- Biology
- 1997
The aim of this review is to clarify issues in relation to GCIs in MSA, by defining their diagnostic and biological significance and by comparing them with other, more recently observed glial changes.
Argentophilic intracytoplasmic inclusions in multiple system atrophy
- BiologyJournal of Neurology
- 2004
It is suggested that the inclusion may be specific to OPCA and related disorders which include PAF and a useful marker to distinguish O PCA from other neurodegenerative diseases.
Structural and immunocytochemical features of olivopontocerebellar atrophy caused by the spinocerebellar ataxia type 1 (SCA-1) mutation define a unique phenotype
- BiologyActa Neuropathologica
- 2004
The type and neuroanatomical distribution of structural lesions were similarly reproduced in all probands at the end stage of SCA-1, to the point that they appeared to constitute a unique phenotype.
Cellular pathology in multiple system atrophy
- BiologyNeuropathology : official journal of the Japanese Society of Neuropathology
- 2006
Two degenerative processes might synergistically cause neuronal depletion in MSA, due to the filamentous aggregation of α‐synuclein in the neurons in several brain regions and the widespread occurrence of GCIs associated with oligodendroglia–myelin degeneration in the central nervous system.
Distribution of neuronal cytoplasmic inclusions in multiple system atrophy.
- BiologyNagoya journal of medical science
- 1995
It is indicated that NCIs represent a special neuronal alteration characteristic of MSA and support the theory that OPCA, SND and SDS represent manifestations of a single condition i.e. MSA.
References
SHOWING 1-10 OF 23 REFERENCES
Electron microscopic structure of the “inclusion bodies” in Pick's disease
- BiologyNeurology
- 1968
Examination of the ultrastructure of these ‘bodies’ offered the opportunity to elucidate the nature of this specific histological alteration in Pick’s disease, and the artefactual problems posed by electron-microscopic examination of formalin-fixed tissue, the rarity of this disease prompted us to accept such technical limitations.
[Striatonigral degeneration associated with olivopontocerebellar atrophy. Anatomo-clinical study of 3 cases. Nosologic discussion].
- Medicine, PsychologyRevue neurologique
- 1983
These cases cannot therefore be considered as a pathological entity but as a particular form of degeneration affecting multiple systems, associated with evidence of olivopontocerebellar degeneration.
Pick's disease. A clinical and ultrastructural study.
- BiologyArchives of neurology
- 1972
Brain biopsy was performed on a 61-year-old woman with a four-year history of progressive dementia and it is proposed that Pick cells are the result of retrograde or transsynaptic degeneration and that the neuron aggregates whatever fibrillar material it has and can make.
Multiple system atrophy with autonomic failure Clinical, histological and neurochemical observations on four cases
- BiologyJournal of the Neurological Sciences
- 1979
The striatonigral degenerations. Putaminal pigments and nosology.
- Biology, MedicineBrain : a journal of neurology
- 1975
Three new cases of striato-nigral degeneration (SND) are presented and the presence of neuromelanin in the putamen suggests that the putaminal atrophy is the primary lesion in SND which is a true supranigral form of parkinsonism.
Ultrastructure of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome.
- ChemistryArchives of neurology
- 1973
The fine structure of neurofibrillary tangles found in the subthalamic bodies and substantia nigra of postmortem brain in one case of Steele-Richardson-Olszewski syndrome was studied with the…
Olivopontocerebellar atrophy A review of 117 cases
- MedicineJournal of the Neurological Sciences
- 1982
Lateral horn cells in progressive autonomic failure
- MedicineJournal of the Neurological Sciences
- 1980
PATHOLOGY OF SHY‐DRAGER SYNDROME*
- MedicineJournal of neuropathology and experimental neurology
- 1979
In four patients with the Shy-Drager syndrome, detailed pathological findings in the central nervous system are described. All four patients had striatonigral degeneration, olivopontocerebellar…
Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy.
- Medicine, PsychologyJournal of neurology, neurosurgery, and psychiatry
- 1969
A detailed post-mortem examination of one of their cases showed neuronal degeneration at many sites, including the intermediolateral columns of the spinal cord, but they did not comment on the relation of this finding to the autonomic features of their patient's disorder.