Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)

@article{Papp1989GlialCI,
  title={Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)},
  author={M{\'a}ty{\'a}s I. Papp and Jacob Kahn and Peter L. Lantos},
  journal={Journal of the Neurological Sciences},
  year={1989},
  volume={94},
  pages={79-100}
}
Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy
TLDR
The studies demonstrate widespread distribution of NCIs in the central nervous system of MSA and suggest the same pathological process that forms the granule-associated filaments in axons may also be responsible for the formation of ubiquitin-positive thickened neurites.
The distribution and dynamic density of oligodendroglial cytoplasmic inclusions (GCIs) in multiple system atrophy: a correlation between the density of GCIs and the degree of involvement of striatonigral and olivopontocerebellar systems
TLDR
GCIs may represent the early changes in MSA and may be a useful neuropathological hallmark for diagnosis of MSA, even in cases with minimal OPCA and SND.
Argyrophilic ubiquitinated cytoplasmic inclusions of Leu-7-positive glial cells in olivopontocerebellar atrophy (multiple system atrophy)
TLDR
The observation that Leu-7-positive glial cells, mainly oligodendroglials cells, had argyrophilic ubiquitinated inclusions may be of significance for the evaluation of the pathology of OPCA(MSA).
Cytoskeletal protein abnormalities in patients with olivopontocerebellar atrophy — an immunocytochemical and Gallyas silver impregnation study
TLDR
Findings indicate that the argyrophilia in the OPCA subjects closely correlates with PHF and tau immunoreactivities.
Multiple System Atrophy
TLDR
The aim of this review is to clarify issues in relation to GCIs in MSA, by defining their diagnostic and biological significance and by comparing them with other, more recently observed glial changes.
Argentophilic intracytoplasmic inclusions in multiple system atrophy
TLDR
It is suggested that the inclusion may be specific to OPCA and related disorders which include PAF and a useful marker to distinguish O PCA from other neurodegenerative diseases.
Structural and immunocytochemical features of olivopontocerebellar atrophy caused by the spinocerebellar ataxia type 1 (SCA-1) mutation define a unique phenotype
TLDR
The type and neuroanatomical distribution of structural lesions were similarly reproduced in all probands at the end stage of SCA-1, to the point that they appeared to constitute a unique phenotype.
Cellular pathology in multiple system atrophy
TLDR
Two degenerative processes might synergistically cause neuronal depletion in MSA, due to the filamentous aggregation of α‐synuclein in the neurons in several brain regions and the widespread occurrence of GCIs associated with oligodendroglia–myelin degeneration in the central nervous system.
Distribution of neuronal cytoplasmic inclusions in multiple system atrophy.
TLDR
It is indicated that NCIs represent a special neuronal alteration characteristic of MSA and support the theory that OPCA, SND and SDS represent manifestations of a single condition i.e. MSA.
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Lateral horn cells in progressive autonomic failure
PATHOLOGY OF SHY‐DRAGER SYNDROME*
In four patients with the Shy-Drager syndrome, detailed pathological findings in the central nervous system are described. All four patients had striatonigral degeneration, olivopontocerebellar
Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy.
TLDR
A detailed post-mortem examination of one of their cases showed neuronal degeneration at many sites, including the intermediolateral columns of the spinal cord, but they did not comment on the relation of this finding to the autonomic features of their patient's disorder.
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