Glial connexin expression and function in the context of Alzheimer's disease.

@article{Koulakoff2012GlialCE,
  title={Glial connexin expression and function in the context of Alzheimer's disease.},
  author={Annette Koulakoff and Xin Mei and Juan Andr{\'e}s Orellana and Juan C S{\'a}ez and Christian Giaume},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1818 8},
  pages={2048-57}
}
A hallmark of neurodegenerative diseases is the reactive gliosis characterized by a phenotypic change in astrocytes and microglia. This glial response is associated with modifications in the expression and function of connexins (Cxs), the proteins forming gap junction channels and hemichannels. Increased Cx expression is detected in most reactive astrocytes located at amyloid plaques, the histopathological lesions typically present in the brain of Alzheimer's patients and animal models of the… CONTINUE READING

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