Glial cells participate in histamine inactivation in vivo

  title={Glial cells participate in histamine inactivation in vivo},
  author={Zsuzsanna Huszti and Helmut Prast and Manh Hung Tran and Hanspeter Fischer and Athineos Philippu},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
The ability of glial cells to take up histamine in vitro suggests that these cells may be involved in histamine inactivation. This prompted us to study the possible interactions between neuronal and glial processes which determine the histamine concentration in the synaptic cleft. In vitro experiments showed that the glial metabolic toxin, fluoroacetate (20 and 40mmol/l) depressed histamine uptake into cultured astroglial cells and dissociated hypothalamic cells of rats. For in vivo… CONTINUE READING
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Release of brain histamine : rhythms and modulation by other neurotransmitters

  • A Philippu
  • Measurement of neurotransmitter release in vivo
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