Glial cells of the oligodendrocyte lineage express proton-activated Na+ channels.

@article{Sontheimer1989GlialCO,
  title={Glial cells of the oligodendrocyte lineage express proton-activated Na+ channels.},
  author={Harald Sontheimer and M Perouansky and Dana Hoppe and Hans Dieter Lux and Rosemarie Grantyn and Helmut Kettenmann},
  journal={Journal of neuroscience research},
  year={1989},
  volume={24 4},
  pages={496-500}
}
Neurons and oligodendrocytes, but not type I astrocytes and Schwann cells, generate large Na+ currents in response to a step increase of [H+]. Proton-activated Na+ channels are the first cationic channels expressed in neuronal precursor cells from the mammalian brain. Glial precursor cells cultured from mouse brain are also capable of generating Na+ currents in response to step acidification (INa(H]. With further development along the oligodendrocyte lineage, this property is retained, whereas… CONTINUE READING
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