Glial cells in the enteric nervous system contain glial fibrillary acidic protein

  title={Glial cells in the enteric nervous system contain glial fibrillary acidic protein},
  author={Kristjan R Jessen and Rhona Mirsky},
The complex nervous networks found throughout the mammalian gut—the enteric nervous system—are histologically, ultrastructurally, and, to some extent, functionally—similar to the central nervous system1–3. The glial cells of the small enteric ganglia are generally classified as Schwann or satellite cells, since they are found in the peripheral nervous system, possess nuclei which ultrastructurally resemble those of Schwann cells and are derived from the neural crest4,5. However, it has been… Expand
Evidence for the presence of S-100 protein in the glial component of the human enteric nervous system
It is demonstrated here, using immunohistochemistry and electron immunocytochemistry, that both enteric glial cells and Schwann cells of the human gut contain densely immunoreactive S-100, and this protein can therefore be regarded as a common marker for the glial components of the enteric nervous system. Expand
Immunocytochemical characterization of supporting cells in the enteric nervous system in Hirschsprung's disease.
GS immunocytochemistry may delineate intrinsic and extrinsic neural components in the ENS, and may provide an important clue for differential diagnosis of Hirschsprung's disease. Expand
Imaging neuron-glia interactions in the enteric nervous system
A number of approaches to unravel the complex neuron-glia crosstalk in the ENS are described, focusing on the challenges and possibilities of live microscopic imaging in both animal models and human tissue samples. Expand
Glial fibrillary acidic polypeptides in peripheral glia Molecular weight, heterogeneity and distribution
The results suggest that the non-myelin-forming cells of the central and peripheral nervous system may share some common functions, and that the glial filament polypeptides of peripheral glia and astrocytes are less closely related in the human than in the rat. Expand
An ultrastructural study of neurons and non-neuronal cells in the myenteric plexus of the rabbit colon
The myenteric plexus of the rabbit colon showed a degree of structural organization that was unusually high for the peripheral nervous system, providing a basis for the complex integrative activityExpand
The enteric nervous system in tissue culture. II. Ultrastructural studies of cell types and their relationships
Tissue culture preparations of the myenteric plexus from the guinea pig taenia coli have been studied by electron microscopy. Three main cell types can be identified: neurons, enteric glial cells andExpand
Immunohistochemical identification of supportive cell types in the enteric nervous system of the rat colon and rectum
It is suggested that in the enteric nervous system the terms “glial cells’ and “Schwann cells” should be employed to designate the supportive cells containing GFA and S- 100 proteins, and cells containing S-100 protein, respectively. Expand
Ultrastructure of the nerve plexuses of the mammalian intestine: The enteric glial cells
The possible significance of these systems of gliofilaments (and the high number of intermediate junctions) is discussed in the light of the severe mechanical stresses imposed on the ganglia by the contractile activity of the gut wall. Expand
Glial fibrillary acidic protein (GFAP) immunoreactivity in enteric ganglia of the chick embryo
From the experiments, it is concluded that neuronal and glial phenotypes are immunohistochemically distinct from as early as day 4.5 of incubation, even if by ultrastructural criteria glial cells are clearly distinguishable from neurons only after day 16 in ovo. Expand


Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture
Although Ran-1 is expressed on glial and neuronal tumours, it was not found on normal astrocytes, oligodendrocyte or neurons and the 'large external transformation sensitive' (LETS) protein could be detected on fibroblasts and leptomeningeal cells but not on neurons or glial cells. Expand
Ultrastructural localization of glial fibrillary acidic protein in mouse cerebellum by immunoperoxidase labeling
Glial fibrillary acidic protein was localized at the electron microscope level in the cerebellum of adult mice by indirect immunoperoxidase histology. In confirmation of previous studies at the lightExpand
Glial Cells in the Myenteric Plexus
  • G. Gabella
  • Chemistry, Medicine
  • Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete
  • 1971
In the myenteric plexus of rat stomach, ileum, and rectum, glial cells outnumber nerve cells by more than 3 to 1; they have several processes which extend between, and adapt themselves to, other cellular elements, constituting a very compact structure. Expand
The topographical distribution of S‐100 and GFA proteins in the adult rat brain: An immunohistochemical study using horseradish peroxidase‐labelled antibodies
The cytological and topographical distribution of S‐100 and glial fibrillary acidic proteins in the adult rat brain has been compared using the horseradish peroxidase‐labelled antibody technique, confirming its association with astrocytic filaments. Expand
Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence.
Abstract The glial fibrillary acidic (GFA) protein, a brain specific protein extracted from severely gliosed human tissue, is not species specific; cross-reaction occurs between anti-human GFAExpand
Thy-1 antigen on astrocytes in long-term cultures of rat central nervous system
The use of monoclonal anti-Thy-1 antiserum in combination with other recently defined neural cell markers is described here to study the distribution of Thy-1 on cells grown in long-term cultures of rat central nervous system and is the first report to identify unambiguously Thy- 1 on astrocytes. Expand
Handbook of Physiology.
This is the first volume of the proposed many-sectioned "Handbook" in which the American Physiological Society intends to present comprehensively the entire field of physiology. The scope and depthExpand
Intermediate filaments as mechanical integrators of cellular space
Five chemically distinct classes of intermediate filaments can be identified within higher eukaryotic cells and may function to integrate mechanically the various structures of the cytoplasmic space in a way that is tailored to the differentiated state of the cell. Expand