Glial cell line-derived neurotrophic factor-levodopa interactions and reduction of side effects in parkinsonian monkeys.

@article{Miyoshi1997GlialCL,
  title={Glial cell line-derived neurotrophic factor-levodopa interactions and reduction of side effects in parkinsonian monkeys.},
  author={Y. Miyoshi and Zhi-Ming Zhang and Aliza Ovadia and Paul A. Lapchak and Frank Collins and Dana C Hilt and Carl R Lebel and Richard Kryscio and Don Marshall Gash},
  journal={Annals of neurology},
  year={1997},
  volume={42 2},
  pages={208-14}
}
Glial cell line-derived neurotrophic factor (GDNF) stimulates the nigrostriatal dopaminergic pathway and improves motor functions in animal models of parkinsonism. Sinemet is currently the most widely used drug for treating Parkinson's disease. The present study has evaluated GDNF-Sinemet interactions in parkinsonian rhesus monkeys. Both GDNF and Sinemet, when given alone, significantly improved total parkinsonian scores. The response to Sinemet did not change after intracerebroventricular… CONTINUE READING

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