Glial cell line-derived neurotrophic growth factor increases motility and survival of cultured mesenchymal stem cells and ameliorates acute kidney injury.

@article{Shi2008GlialCL,
  title={Glial cell line-derived neurotrophic growth factor increases motility and survival of cultured mesenchymal stem cells and ameliorates acute kidney injury.},
  author={Haikun Shi and D Patschan and Gunnar P. H. Dietz and Mathias B{\"a}hr and Matthew D. Plotkin and Michael S. Goligorsky},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={294 1},
  pages={F229-35}
}
Glial cell line-derived neurotrophic growth factor (GDNF), a member of the transforming growth factor family, is necessary for renal organogenesis and exhibits changes in expression in models of renal disease. Nestin is an intermediate filament protein originally believed to be a marker of neuroepithelial stem cells and recently proposed as a marker of mesenchymal stem cells (MSC). Having demonstrated the participation of nestin-expressing cells in renoprotection during acute renal ischemia, we… CONTINUE READING
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