• Medicine
  • Published in Pancreas 2004

Glial cell line-derived neurotrophic factor enhances nuclear factor-kappaB activity and invasive potential in human pancreatic cancer cells.

@article{Takahashi2004GlialCL,
  title={Glial cell line-derived neurotrophic factor enhances nuclear factor-kappaB activity and invasive potential in human pancreatic cancer cells.},
  author={Hiroki Takahashi and Hitoshi Funahashi and Hirozumi Sawai and Masaki Sakamoto and Yoichi Matsuo and Minoru Yamamoto and Yuji Okada and Tetsushi Hayakawa and Tadao Manabe},
  journal={Pancreas},
  year={2004},
  volume={29 1},
  pages={
          22-7
        }
}
OBJECTIVES The invasive potential is increased by glial cell line-derived neurotrophic factor (GDNF) in human pancreatic cancer cell lines. We researched whether the signaling pathway activated by GDNF correlates with the nuclear factor-kappaB (NF-kappaB) in human pancreatic cancer cell lines and whether the inhibition of NF-kappaB activity is associated with suppression of invasive potential. METHODS Proliferation of human pancreatic cancer cell lines (BxPC-3 and MIA PaCa-2) was measured by… CONTINUE READING