Glial cell line-derived neurotrophic factor: characterization of mammalian posttranslational modifications.

@article{Piccinini2013GlialCL,
  title={Glial cell line-derived neurotrophic factor: characterization of mammalian posttranslational modifications.},
  author={Elisa Piccinini and Nisse Kalkkinen and Mart Saarma and Pia Runeberg-Roos},
  journal={Annals of medicine},
  year={2013},
  volume={45 1},
  pages={66-73}
}
INTRODUCTION Although glial cell line-derived neurotrophic factor (GDNF) has a strong clinical potential, little is known of how the posttranslational modifications of GDNF affect its biological activity and therapeutic potential. In mammalian cells GDNF is synthesized as a preproprotein. During secretion GDNF dimerizes, folds with -S-S- bonds, is modified… CONTINUE READING