Corpus ID: 1547918

Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina.

@article{Hojo2000GlialCF,
  title={Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina.},
  author={Masato Hojo and Toshiyuki Ohtsuka and Nobuo Hashimoto and G{\'e}rard Gradwohl and François Guillemot and Ryoichiro Kageyama},
  journal={Development},
  year={2000},
  volume={127 12},
  pages={
          2515-22
        }
}
Neurons and glial cells differentiate from common precursors. Whereas the gene glial cells missing (gcm) determines the glial fate in Drosophila, current data about the expression patterns suggest that, in mammals, gcm homologues are unlikely to regulate gliogenesis. Here, we found that, in mouse retina, the bHLH gene Hes5 was specifically expressed by differentiating Müller glial cells and that misexpression of Hes5 with recombinant retrovirus significantly increased the population of glial… Expand
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  • 2001
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