Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer.

@article{Okada2003GlialCN,
  title={Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer.},
  author={Yuji Okada and Guido Eibl and John Peter Duffy and Howard A. Reber and Oscar Joe Hines},
  journal={Surgery},
  year={2003},
  volume={134 2},
  pages={293-9}
}
BACKGROUND We have previously reported that the glial cell-derived neurotrophic factor (GDNF) promotes pancreatic cancer cell invasion in vitro. The purpose of this study was to determine whether GDNF regulates the expression and activation of matrix metalloproteinase-9 (MMP-9) in human pancreatic cancer cells. METHODS We used human pancreatic cancer cell line MIA PaCa-2. The effect of GDNF on mRNA and protein expression was measured by Northern blot, Western blot and enzyme-linked… CONTINUE READING

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