Glial cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

@inproceedings{Ibiza2016GlialCN,
  title={Glial cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence},
  author={Sales Ibiza and Bethania Garc{\'i}a-Cassani and Helder S. Ribeiro and T{\^a}nia Carvalho and Lu{\'i}s Neves de Almeida and Rute Marques and Ana M Misic and Casey Bartow-McKenney and Denise M. Larson and William J. Pavan and G{\'e}rard Eberl and Elizabeth A. Grice and Henrique Veiga-Fernandes},
  booktitle={Nature},
  year={2016}
}
Group 3 innate lymphoid cells (ILC3) are major regulators of inflammation and infection at mucosal barriers. ILC3 development is thought to be programmed, but how ILC3 perceive, integrate and respond to local environmental signals remains unclear. Here we show that ILC3 in mice sense their environment and control gut defence as part of a glial–ILC3–epithelial cell unit orchestrated by neurotrophic factors. We found that enteric ILC3 express the neuroregulatory receptor RET. ILC3-autonomous Ret… CONTINUE READING

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