Glial activation: a driving force for pathological pain

  title={Glial activation: a driving force for pathological pain},
  author={L. Watkins and E. Milligan and S. Maier},
  journal={Trends in Neurosciences},
  • L. Watkins, E. Milligan, S. Maier
  • Published 2001
  • Medicine
  • Trends in Neurosciences
  • Pain is classically viewed as being mediated solely by neurons, as are other sensory phenomena. The discovery that spinal cord glia (microglia and astrocytes) amplify pain requires a change in this view. These glia express characteristics in common with immune cells in that they respond to viruses and bacteria, releasing proinflammatory cytokines, which create pathological pain. These spinal cord glia also become activated by certain sensory signals arriving from the periphery. Similar to… CONTINUE READING
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