Glial Nax Channels Control Lactate Signaling to Neurons for Brain [Na+] Sensing

  title={Glial Nax Channels Control Lactate Signaling to Neurons for Brain [Na+] Sensing},
  author={Hidetada Shimizu and Eiji Watanabe and Takeshi Y. Hiyama and Ayano Nagakura and Akihiro Fujikawa and Haruo Okado and Yuchio Yanagawa and Kunihiko Obata and Masaharu Noda},
Sodium (Na) homeostasis is crucial for life, and Na levels in body fluids are constantly monitored in the brain. The subfornical organ (SFO) is the center of the sensing responsible for the control of salt-intake behavior, where Na(x) channels are expressed in specific glial cells as the Na-level sensor. Here, we show direct interaction between Na(x) channels and alpha subunits of Na(+)/K(+)-ATPase, which brings about Na-dependent activation of the metabolic state of the glial cells. The… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
81 Citations
35 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 81 extracted citations


Publications referenced by this paper.
Showing 1-10 of 35 references

and functional roles in brain cells

  • T. Y. Hiyama, E. Watanabe, H. Okado, M. Noda
  • J. Neurosci. Res
  • 2004
Highly Influential
7 Excerpts

on a day/night cycle graded according to the duration of deprivation

  • C. P. Chih, P. Lipton, Roberts, E. L.
  • Brain Res.,
  • 2001
Highly Influential
4 Excerpts

Na,K)-ATPase by an electric field

  • O. I. Shamraj, J. B. Lingrel
  • J. Biol. Chem
  • 1994
Highly Influential
4 Excerpts

localized perfusion within the third cerebral ventricle of sheep

  • D. A. Denton, M. J. McKinley, R. S. Weisinger
  • Am. J. Physiol. Regul. Integr. Comp. Physiol
  • 1996
Highly Influential
5 Excerpts

properties of the rat Na/K-ATPase alpha 1, alpha 2, and alpha 3 isoforms expressed in HeLa cells

  • A. K. Johnson, P. M. Gross
  • J. Biol. Chem
  • 1993
Highly Influential
3 Excerpts

Na-level-sensitive Na channel Nax is expressed in glial laminate processes in the sensory circumventricular organs

  • Y. Yanagawa, K. Obata, M. Noda
  • Am. J
  • 2006

Similar Papers

Loading similar papers…