Glial Nax Channels Control Lactate Signaling to Neurons for Brain [Na+] Sensing

@article{Shimizu2007GlialNC,
  title={Glial Nax Channels Control Lactate Signaling to Neurons for Brain [Na+] Sensing},
  author={Hidetada Shimizu and Eiji Watanabe and Takeshi Y. Hiyama and Ayano Nagakura and Akihiro Fujikawa and Haruo Okado and Yuchio Yanagawa and Kunihiko Obata and Masaharu Noda},
  journal={Neuron},
  year={2007},
  volume={54},
  pages={59-72}
}
Sodium (Na) homeostasis is crucial for life, and Na levels in body fluids are constantly monitored in the brain. The subfornical organ (SFO) is the center of the sensing responsible for the control of salt-intake behavior, where Na(x) channels are expressed in specific glial cells as the Na-level sensor. Here, we show direct interaction between Na(x) channels and alpha subunits of Na(+)/K(+)-ATPase, which brings about Na-dependent activation of the metabolic state of the glial cells. The… CONTINUE READING
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