Glial Growth Factor/Neuregulin Inhibits Schwann Cell Myelination and Induces Demyelination

@article{Zanazzi2001GlialGF,
  title={Glial Growth Factor/Neuregulin Inhibits Schwann Cell Myelination and Induces Demyelination},
  author={G. Zanazzi and S. Einheber and R. Westreich and Melanie-Jane Hannocks and D. Bedell-Hogan and M. Marchionni and J. Salzer},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={152},
  pages={1289 - 1300}
}
During development, neuregulin-1 promotes Schwann cell proliferation and survival; its role in later events of Schwann cell differentiation, including myelination, is poorly understood. Accordingly, we have examined the effects of neuregulin-1 on myelination in neuron-Schwann cell cocultures. Glial growth factor (GGF), a neuregulin-1 isoform, significantly inhibited myelination by preventing axonal segregation and ensheathment. Basal lamina formation was not affected. Treatment of established… Expand
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References

SHOWING 1-10 OF 64 REFERENCES
Transforming growth factor-beta blocks myelination but not ensheathment of axons by Schwann cells in vitro
  • V. Guénard, L. Gwynn, P. Wood
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
  • 69
  • PDF
Glial Growth Factor 2, a Soluble Neuregulin, Directly Increases Schwann Cell Motility and Indirectly Promotes Neurite Outgrowth
  • 187
  • PDF
Cell death in the Schwann cell lineage and its regulation by neuregulin.
  • 239
  • PDF
GGF/Neuregulin Induces a Phenotypic Reversion of Oligodendrocytes
  • 100
Transforming growth factor-beta 1 regulates axon/Schwann cell interactions
  • 139
  • PDF
Expression of Neuregulins and their Putative Receptors, ErbB2 and ErbB3, Is Induced during Wallerian Degeneration
  • 320
  • Highly Influential
  • PDF
Schwann cell proliferation and migration during paranodal demyelination
  • J. Griffin, N. Drucker, +5 authors E. Stocks
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1987
  • 78
  • PDF
Axonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination
  • 192
  • PDF
...
1
2
3
4
5
...