Glial Growth Factor/Neuregulin Inhibits Schwann Cell Myelination and Induces Demyelination

@article{Zanazzi2001GlialGF,
  title={Glial Growth Factor/Neuregulin Inhibits Schwann Cell Myelination and Induces Demyelination},
  author={G Zanazzi and Steven Einheber and Richard W Westreich and Melanie-Jane Hannocks and Debra Bedell-Hogan and Mark A. Marchionni and James L Salzer},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={152},
  pages={1289 - 1300}
}
  • G Zanazzi, Steven Einheber, +4 authors James L Salzer
  • Published in The Journal of cell biology 2001
  • Medicine, Biology
  • The Journal of Cell Biology
  • During development, neuregulin-1 promotes Schwann cell proliferation and survival; its role in later events of Schwann cell differentiation, including myelination, is poorly understood. Accordingly, we have examined the effects of neuregulin-1 on myelination in neuron-Schwann cell cocultures. Glial growth factor (GGF), a neuregulin-1 isoform, significantly inhibited myelination by preventing axonal segregation and ensheathment. Basal lamina formation was not affected. Treatment of established… CONTINUE READING

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