Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus

  title={Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus},
  author={Yuki Yasumoto and Hirofumi Miyazaki and Masaki Ogata and Yoshiteru Kagawa and Yui Yamamoto and Ariful Islam and Tetsuya Yamada and Hideki Katagiri and Yuji Owada},
  journal={Molecular Neurobiology},
The hypothalamus is involved in the regulation of food intake and energy homeostasis. [] Key Method We performed a phenotypic analysis of diet-induced FABP7 knockout (KO) obese mice and of FABP7 KO mice treated with a single leptin injection. Immunohistochemistry revealed that FABP7+ cells are NG2+ or GFAP+ in the ARC and ME. In mice fed a high-fat diet, weight gain and food intake were lower in FABP7 KO mice than in wild-type (WT) mice. FABP7 KO mice also had lower food intake and weight gain after a single…
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