Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling

@article{Hardaway2015GlialEO,
  title={Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling},
  author={J. Andrew Hardaway and Sarah M. Sturgeon and Chelsea L. Snarrenberg and Zhaoyu Li and X Z Shawn Xu and Daniel P. Bermingham and Peace Odiase and William C Spencer and David M. Miller and Lucia Carvelli and Shannon L. Hardie and Randy D. Blakely},
  journal={The Journal of Neuroscience},
  year={2015},
  volume={35},
  pages={9409 - 9423}
}
Glial cells play a critical role in shaping neuronal development, structure, and function. In a screen for Caenorhabditis elegans mutants that display dopamine (DA)-dependent, Swimming-Induced Paralysis (Swip), we identified a novel gene, swip-10, the expression of which in glia is required to support normal swimming behavior. swip-10 mutants display reduced locomotion rates on plates, consistent with our findings of elevated rates of presynaptic DA vesicle fusion using fluorescence recovery… 

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