Glial Cells Mediate Target Layer Selection of Retinal Axons in the Developing Visual System of Drosophila

  title={Glial Cells Mediate Target Layer Selection of Retinal Axons in the Developing Visual System of Drosophila},
  author={Burkhard Poeck and Susanne Fischer and Dorian Gunning and S.Lawrence Zipursky and Iris Salecker},
In the fly visual system, each class of photoreceptor neurons (R cells) projects to a different synaptic layer in the brain. R1-R6 axons terminate in the lamina, while R7 and R8 axons pass through the lamina and stop in the medulla. As R cell axons enter the lamina, they encounter both glial cells and neurons. The cellular requirement for R1-R6 targeting was determined using loss-of-function mutations affecting different cell types in the lamina. nonstop (encoding a ubiquitin-specific protease… CONTINUE READING

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