Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice.

@article{Verd2008GliadindependentNA,
  title={Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice.},
  author={Elena F. Verd{\'u} and Xiongfei Huang and Jane Mea Natividad and Jianyun Lu and Patricia A Blennerhassett and Chella S. David and D M McKay and J A Murray},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={294 1},
  pages={G217-25}
}
Celiac disease is a gluten intolerance caused by a T-cell response against human leukocyte antigen (HLA)-DQ2 and DQ8-bound gluten peptides. Some subjects experience gastrointestinal symptoms in the absence of villous atrophy. Here we investigate the potential mechanisms of gut dysfunction in gluten-sensitive HLA-DQ8 transgenic mice. HLA-DQ8 mice were sensitized and gavaged with gliadin 3x/wk for 3 wk (G/G). Controls included 1) nonsensitized mice gavaged with rice (C); 2) gliadin-sensitized… CONTINUE READING