Gliadin T Cell Epitope Selection by Tissue Transglutaminase in Celiac Disease

  title={Gliadin T Cell Epitope Selection by Tissue Transglutaminase in Celiac Disease},
  author={B. Fleckenstein and {\O}. Molberg and S. Qiao and D. Schmid and F. von der Mülbe and K. Elgst{\o}en and G. Jung and L. Sollid},
  journal={The Journal of Biological Chemistry},
  pages={34109 - 34116}
  • B. Fleckenstein, Ø. Molberg, +5 authors L. Sollid
  • Published 2002
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • Tissue transglutaminase (TG2) can modify proteins by transamidation or deamidation of specific glutamine residues. TG2 has a major role in the pathogenesis of celiac disease as it is both the target of disease-specific autoantibodies and generates deamidated gliadin peptides that are recognized by CD4+, DQ2-restricted T cells from the celiac lesions. Capillary electrophoresis with fluorescence-labeled gliadin peptides was used to separate and quantify deamidated and transamidated products. In a… CONTINUE READING
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