Gliadin T Cell Epitope Selection by Tissue Transglutaminase in Celiac Disease

  title={Gliadin T Cell Epitope Selection by Tissue Transglutaminase in Celiac Disease},
  author={Burkhard T. Fleckenstein and {\O}yvind Molberg and Shuo-Wang Qiao and Dietmar G. Schmid and Florian von der Mülbe and Katja Elgst{\o}en and Günther Jung and Ludvig M. Sollid},
  journal={The Journal of Biological Chemistry},
  pages={34109 - 34116}
Tissue transglutaminase (TG2) can modify proteins by transamidation or deamidation of specific glutamine residues. TG2 has a major role in the pathogenesis of celiac disease as it is both the target of disease-specific autoantibodies and generates deamidated gliadin peptides that are recognized by CD4+, DQ2-restricted T cells from the celiac lesions. Capillary electrophoresis with fluorescence-labeled gliadin peptides was used to separate and quantify deamidated and transamidated products. In a… 

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The Preferred Substrates for Transglutaminase 2 in a Complex Wheat Gluten Digest Are Peptide Fragments Harboring Celiac Disease T-Cell Epitopes

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