Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia.

  title={Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia.},
  author={Masamitsu Iino and Koaru Goto and Wataru Kakegawa and Haruo Okado and Makoto Sudo and Shogo Ishiuchi and Akiko Miwa and Yukihiro Takayasu and Izumu Saito and Keisuke Tsuzuki and Seiji Ozawa},
  volume={292 5518},
Glial cells express a variety of neurotransmitter receptors. Notably, Bergmann glial cells in the cerebellum have Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) assembled without the GluR2 subunit. To elucidate the role of these Ca2+-permeable AMPARs, we converted them into Ca2+-impermeable receptors by adenoviral-mediated delivery of the GluR2 gene. This conversion retracted the glial processes ensheathing synapses on Purkinje… CONTINUE READING
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