Glia-like Stem Cells Sustain Physiologic Neurogenesis in the Adult Mammalian Carotid Body

@article{Pardal2007GlialikeSC,
  title={Glia-like Stem Cells Sustain Physiologic Neurogenesis in the Adult Mammalian Carotid Body},
  author={Ricardo Pardal and Patricia Ortega-S{\'a}enz and Roc{\'i}o Dur{\'a}n and Jos{\'e} L{\'o}pez-Barneo},
  journal={Cell},
  year={2007},
  volume={131},
  pages={364-377}
}
Neurogenesis is known to occur in the specific niches of the adult mammalian brain, but whether germinal centers exist in the neural-crest-derived peripheral nervous system is unknown. We have discovered stem cells in the adult carotid body (CB), an oxygen-sensing organ of the sympathoadrenal lineage that grows in chronic hypoxemia. Production of new neuron-like CB glomus cells depends on a population of stem cells, which form multipotent and self-renewing colonies in vitro. Cell fate mapping… CONTINUE READING
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