Glia-derived signals induce synapse formation in neurones of the rat central nervous system.

@article{Ngler2001GliaderivedSI,
  title={Glia-derived signals induce synapse formation in neurones of the rat central nervous system.},
  author={Karl N{\"a}gler and Daniela H Mauch and Frank W Pfrieger},
  journal={The Journal of physiology},
  year={2001},
  volume={533 Pt 3},
  pages={665-79}
}
1. To study the effects of glial cells on synapse formation, we established microcultures of purified rat retinal ganglion cells (RGCs) and monitored synapse (autapse) development in single neurones using electrophysiological recordings, FM1-43 labelling and immunocytochemistry. 2. Solitary neurones grew ramifying neurites, but formed only very few and inefficient excitatory autapses, when cultured for up to 2 weeks in defined medium and in the absence of glial cells. 3. Treatment of glia-free… CONTINUE READING

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