Glia cell stimulating factor (GSF): A new lymphokine: Part 1. Cellular sources and partial purification of murine GSF, role of cytoskeleton and protein synthesis in its production

@article{Fontana1982GliaCS,
  title={Glia cell stimulating factor (GSF): A new lymphokine: Part 1. Cellular sources and partial purification of murine GSF, role of cytoskeleton and protein synthesis in its production},
  author={A. Fontana and R. Dubs and R. Merchant and S. Balsiger and P. Grob},
  journal={Journal of Neuroimmunology},
  year={1982},
  volume={2},
  pages={55-71}
}
  • A. Fontana, R. Dubs, +2 authors P. Grob
  • Published 1982
  • Biology, Medicine
  • Journal of Neuroimmunology
    • The effect of activated-lymphocyte supernatant on glia cells was investigated. When treated in vitro with Concanavalin A (ConA), murine spleen cells released a soluble product, termed glia cell stimulating factor (GSF), which stimulated RNA and DNA synthesis in cultured murine glia cells. Furthermore, GSF appeared to promote the maturation of undifferentiated glia cells to astrocytes having a high content of glial fibrillary acidic protein. GSF secretion occurred after a lag period of 16 hours… CONTINUE READING
    View on Elsevier
    doi.org
    62 Citations
    Background Citations
    3
    62 Citations
    Citation Type

    Citation Type

    Glia cell stimulating factor (GSF): A new lymphokine: Part 2. Cellular sources and partial purification of human GSF
    • 41
    Involvement of cyclic AMP in the regulations of lymphokine induced glia cell stimulation.
    • 7
    Astrocyte growth enhanced by culture supernatant of a cloned rat thymic myoid cell
    • 2
    Brain basic fibroblast growth factor stimulates the release of plasminogen activators by newborn rat cultured astroglial cells
    • 63
    Mitogen-activated lymphocytes of normals and glioma patients produce factors with anti-glioblastoma activity in vitro
    • 10
    Multiple sclerosis: effects of activated T-lymphocyte-derived products on organ cultures of nervous tissue
    • 12
    Products of activated lymphocytes stimulate Schwann cell mitosis in vitro
    • 11
    Regulation of an oligodendrocyte progenitor cell line by the interleukin‐6 family of cytokines
    • 126
    MHC Class II expression by human glioma cells after in vitro incubation with soluble antigens
    • 17
    Expression of H-2 antigen on oligodendrocytes is induced by soluble factors from concanavalin A activated T cells
    • 22

    References

    SHOWING 1-10 OF 37 REFERENCES
    In vitro stimulation of glia cells by a lymphocyteproduced factor
    • 74
    Involvement of cyclic AMP in the regulations of lymphokine induced glia cell stimulation.
    • 7
    Physiology of mixed leukocyte reaction suppressor factor. I. Role of cytoskeleton and protein synthesis in production and secretion.
    • 7
    Lymphokine-like factors produced by human lymphoid cell lines with B or T cell surface markers.
    • 49
    Macrophage-lymphocyte synergy in the production of osteoclast activating factor.
    • 118
    INDUCTION OF GUINEA PIG B-CELL LYMPHOKINE SYNTHESIS BY MITOGENIC AND NONMITOGENIC SIGNALS TO Fc, Ig, AND C3 RECEPTORS
    • 103
    • PDF
    Release of prostaglandin by mitogen- and antigen-stimulated leukocytes in culture.
    • 155
    • PDF
    Production of macrophage migration inhibitory factor and lymphotoxin by leukocytes from normal and Wiskott-Aldrich syndrome patients.
    • 14
    Induced glial differentiation of fetal rat brain cells in culture: An ultrastructural study
    • 52
    Biochemical and ultrastructural studies of cultured rat astroglial cells: effect of brain extract and dibutyryl cyclic AMP on glial fibrillary acidic protein and glial filaments.
    • 165