Glia cell stimulating factor (GSF): A new lymphokine: Part 1. Cellular sources and partial purification of murine GSF, role of cytoskeleton and protein synthesis in its production

@article{Fontana1982GliaCS,
  title={Glia cell stimulating factor (GSF): A new lymphokine: Part 1. Cellular sources and partial purification of murine GSF, role of cytoskeleton and protein synthesis in its production},
  author={A. Fontana and R. Dubs and R. Merchant and S. Balsiger and P. Grob},
  journal={Journal of Neuroimmunology},
  year={1982},
  volume={2},
  pages={55-71}
}
  • A. Fontana, R. Dubs, +2 authors P. Grob
  • Published 1982
  • Biology, Medicine
  • Journal of Neuroimmunology
  • The effect of activated-lymphocyte supernatant on glia cells was investigated. When treated in vitro with Concanavalin A (ConA), murine spleen cells released a soluble product, termed glia cell stimulating factor (GSF), which stimulated RNA and DNA synthesis in cultured murine glia cells. Furthermore, GSF appeared to promote the maturation of undifferentiated glia cells to astrocytes having a high content of glial fibrillary acidic protein. GSF secretion occurred after a lag period of 16 hours… CONTINUE READING
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