Glia are a unique substrate for the in vitro growth of central nervous system neurons.

  title={Glia are a unique substrate for the in vitro growth of central nervous system neurons.},
  author={Mark Noble and J Fok-Seang and James R. Cohen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={4 7},
We have examined the consequences of surface interactions with glial and nonglial cells on the in vitro growth of CNS neurons. When cerebellar or spinal cord cells were plated onto monolayers highly enriched in cortical astrocytes or sciatic nerve Schwann cells, neurons generally grew as single cells and showed relatively little tendency to aggregate. Similarly, neurites showed little tendency to fasciculate. In contrast, when plated onto fibroblast, heart muscle-fibroblast, or astrocyte-free… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 91 extracted citations


Publications referenced by this paper.
Showing 1-10 of 51 references

The growth of olfactory neurons in short term cultures of rat olfactory epithelium

  • H. O. Nornes
  • Neurosci . Lett .
  • 1984

course of nerve fibers in tissue culture. II. The mechanisms of fasciculation

  • M. Noble, P. S. Mallaburn, N. Klein
  • Z. Zellforsch. Mikrosk. Anat
  • 1984

Two types of astrocytes in cultures of developing rat white matter : Differences in morphology , surface gangliosides , and growth characteristics

  • M. C. Raff, E. R. Abney, M. Noble
  • Brain Res .
  • 1983

Similar Papers

Loading similar papers…