Glia Maturation Factor Deficiency Suppresses 1-Methyl-4-Phenylpyridinium-Induced Oxidative Stress in Astrocytes

@article{Khan2013GliaMF,
  title={Glia Maturation Factor Deficiency Suppresses 1-Methyl-4-Phenylpyridinium-Induced Oxidative Stress in Astrocytes},
  author={Mohammad Moshahid Khan and Duraisamy Kempuraj and Smita Zaheer and Asgar Zaheer},
  journal={Journal of Molecular Neuroscience},
  year={2013},
  volume={53},
  pages={590-599}
}
Inflammation is closely intertwined with pathogenesis of Parkinson’s disease (PD). Increasing evidence suggests that inhibition of glia-mediated inflammation might represent a promising therapeutic target for PD. Glia maturation factor (GMF), an inflammatory protein, predominantly localized in astrocytes is previously isolated, sequenced and cloned in our laboratory. In the present investigation, we demonstrate that GMF-deficiency in astrocytes upregulates the antioxidant status and limit the… CONTINUE READING
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