Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory

@article{Panatier2006GliaDerivedDC,
  title={Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory},
  author={Aude Panatier and Dionysia T. Theodosis and Jean-Pierre Mothet and Bastien Touquet and Loredano Pollegioni and Dominique A. Poulain and St{\'e}phane Henri Richard Oliet},
  journal={Cell},
  year={2006},
  volume={125},
  pages={775-784}
}
The NMDA receptor is a key player in excitatory transmission and synaptic plasticity in the central nervous system. Its activation requires the binding of both glutamate and a co-agonist like D-serine to its glycine site. As D-serine is released exclusively by astrocytes, we studied the physiological impact of the glial environment on NMDA receptor-dependent activity and plasticity. To this end, we took advantage of the changing astrocytic ensheathing of neurons occurring in the supraoptic… Expand
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  • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
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TLDR
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