Glia: silent partners in energy homeostasis and obesity pathogenesis

  title={Glia: silent partners in energy homeostasis and obesity pathogenesis},
  author={John D. Douglass and Mauricio D. Dorfman and Joshua P. Thaler},
Body weight stability requires homeostatic regulation to balance energy intake and energy expenditure. Research on this system and how it is affected by obesity has largely focused on the role of hypothalamic neurons as integrators of information about long-term fuel storage, short-term nutrient availability and metabolic demand. Recent studies have uncovered glial cells as additional contributors to energy balance regulation and obesity pathogenesis. Beginning with early work on leptin… CONTINUE READING
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