Glia: novel counter-regulators of opioid analgesia.

  title={Glia: novel counter-regulators of opioid analgesia.},
  author={Linda R. Watkins and Mark R Hutchinson and Ian Neville Johnston and Steven F. Maier},
  journal={Trends in neurosciences},
  volume={28 12},
Development of analgesic tolerance and withdrawal-induced pain enhancement present serious difficulties for the use of opioids for pain control. Although neuronal mechanisms to account for these phenomena have been sought for many decades, their bases remain unresolved. Within the past four years, a novel non-neuronal candidate has been uncovered that opposes acute opioid analgesia and contributes to development of opioid tolerance and tolerance-associated pain enhancement. This novel candidate… CONTINUE READING

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