Glia: listening and talking to the synapse

@article{Haydon2001GliaLA,
  title={Glia: listening and talking to the synapse},
  author={Philip G Haydon},
  journal={Nature Reviews Neuroscience},
  year={2001},
  volume={2},
  pages={185-193}
}
  • P. Haydon
  • Published 1 March 2001
  • Biology
  • Nature Reviews Neuroscience
Glial cells are emerging from the background to become more prominent in our thinking about integration in the nervous system. Given that glial cells associated with synapses integrate neuronal inputs and can release transmitters that modulate synaptic activity, it is time to rethink our understanding of the wiring diagram of the nervous system. It is no longer appropriate to consider solely neuron–neuron connections; we also need to develop a view of the intricate web of active connections… 
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References

SHOWING 1-10 OF 107 REFERENCES
Control of synapse number by glia.
TLDR
It is shown that few synapses form in the absence of glial cells and that the fewsynapses that do form are functionally immature, and that CNS synapse number can be profoundly regulated by nonneuronal signals.
Neuroglial networks: Neurons and glia talk to each other
Synaptic efficacy enhanced by glial cells in vitro.
TLDR
Developing neurons in culture form inefficient synapses that require glial signals to become fully functional, and the role of glial cells in synapse formation and function was studied in cultures of purified neurons from the rat central nervous system.
Neural circuits in the 21st century: synaptic networks of neurons and glia.
  • J. Loturco
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2000
TLDR
Research showing that glia express neurotransmitter receptors, release neurotransmitter, and propagate intracellular calcium waves indicates that synaptic information flows through the nervous system via glial/neuronal networks.
Neural circuits in the 21 st century : Synaptic networks of neurons and glia
TLDR
A classical synaptic connection between neurons and glia is demonstrated, the first to be both physiologically and structurally defined in the central nervous system, and it will certainly stimulate a search for other varieties of neuro-glia synapses.
Microdomains for neuron–glia interaction: parallel fiber signaling to Bergmann glial cells
Astrocytes are considered a reticulate network of cells, through which calcium signals can spread easily. In Bergmann glia, astrocytic cells of the cerebellum, we identified subcellular compartments
Do astrocytes process neural information?
Direct signaling from astrocytes to neurons in cultures of mammalian brain cells.
TLDR
Astrocytes are shown to directly modulate the free cytosolic calcium, and hence transmission characteristics, of neighboring neurons, which suggests that the astrocytic-neuronal signaling is mediated through intercellular connections rather than synaptically.
Functional Coupling between Neurons and Glia
TLDR
Heterocellular coupling is extended to interactions between neurons and glia, extending the mechanisms by which glia participate in the network properties of the LC in which the degree of coupling is thought to influence cognitive performance.
...
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