Glia, cytokines, and neurotoxicity.

  title={Glia, cytokines, and neurotoxicity.},
  author={Chun Cheih Chao and Shirley X Hu and Phillip K. Peterson},
  journal={Critical reviews in neurobiology},
  volume={9 2-3},
Activated glial cells (microglia and astrocytes) are a hallmark of several neurodegenerative disorders. A growing body of evidence supports the hypothesis that activation of glial cells by cytokines contributes to neurotoxicity. Although the precise mechanisms underlying glia-mediated neurotoxicity are unclear, it has been proposed that the generation of toxic free radicals or other neurotoxins is involved. This review focuses on the role of immune mediators released by activated glial cells in… CONTINUE READING

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