Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development

@article{Barna2005Gli3AP,
  title={Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development},
  author={Maria Barna and Pier Paolo Pandolfi and Lee Niswander},
  journal={Nature},
  year={2005},
  volume={436},
  pages={277-281}
}
The vertebrate limb initially develops as a bud of mesenchymal cells that subsequently aggregate in a proximal to distal (P–D) sequence to give rise to cartilage condensations that prefigure all limb skeletal components. Of the three cardinal limb axes, the mechanisms that lead to establishment and patterning of skeletal elements along the P–D axis are the… CONTINUE READING