Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification.

@article{Kan2018Gli1labeledAM,
  title={Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification.},
  author={Chen Kan and Lijun Chen and Yangyang Hu and Na Ding and Yuyun Li and Tammy L. Mcguire and Haimei Lu and John A Kessler and Lixin Kan},
  journal={Bone},
  year={2018},
  volume={109},
  pages={71-79}
}
Heterotopic ossification (HO), acquired or hereditary, endochondral or intramembranous, is the formation of true bone outside the normal skeleton. Since perivascular Gli1+ progenitors contribute to injury induced organ fibrosis, and CD133 is expressed by a variety of populations of adult stem cells, this study utilized Cre-lox based genetic lineage tracing… CONTINUE READING